Dopamine and dopamine receptor D1 associated with decreased social interaction
| Autor: | Jieyun Shi, Tieqiao Wen, Qiang Liu, Rongfei Lin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nervous system Agonist Male medicine.drug_class Dopamine Nerve Tissue Proteins Hippocampus 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Dopamine receptor D1 Social cognition medicine Animals Interpersonal Relations Mice Knockout Neuronal Plasticity Mechanism (biology) Receptors Dopamine D1 Excitatory Postsynaptic Potentials Membrane Proteins medicine.disease Social relation Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Dopamine Agonists Autism 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural brain research. 324 |
| ISSN: | 1872-7549 |
| Popis: | Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders. |
| Databáze: | OpenAIRE |
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