The Transformation of a Nonfunctioning Islet Cell Tumor of the Pancreas into a Proinsulinoma under Conditions of Lung Metastasis
| Autor: | Masato Yoshioka, Masatake Iida, Yuzo Yamamoto, Go Watanabe, Toshiaki Yoshioka, Satoshi Shibata, Makoto Yoshida, Hideaki Miyazawa, Hiroshi Nanjo, Hiroshi Uchinami |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Lung Neoplasms Antineoplastic Agents Hormonal endocrine system diseases Mitomycin medicine.medical_treatment Autopsy Octreotide Deoxycytidine Nephrectomy Metastasis Fatal Outcome Pancreatectomy Gastrectomy Antineoplastic Combined Chemotherapy Protocols Internal Medicine medicine Humans Colectomy Aged Proinsulin Chemotherapy geography Lung geography.geographical_feature_category business.industry General surgery Diazoxide General Medicine Islet medicine.disease Gemcitabine Hypoglycemia Pancreatic Neoplasms medicine.anatomical_structure Concomitant Disease Progression Carcinoma Islet Cell Female Fluorouracil Pancreas business |
| Zdroj: | Internal Medicine. 54:785-790 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.54.3772 |
| Popis: | We herein report the first case of a nonfunctioning islet cell tumor that transformed into a proinsulinoma during the process of metastasis to the lungs. This phenomenon was confirmed in a 69-year-old woman with an advanced pancreatic islet cell tumor and multiple liver metastases who later developed multiple lung metastases. She underwent pancreatic resection followed by the administration of chemotherapy and survived for seven years. Although the patient initially had hyperglycemia due to diabetes mellitus, she conversely began to manifest hypoglycemic attacks 63 months postoperatively with the concomitant development of multiple lung metastases. An autopsy revealed that only the tumor in the lungs produced proinsulin; no other hormones were detected. |
| Databáze: | OpenAIRE |
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