Cross‐fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods
| Autor: | L. Hrubá, Marie Pometlová, Romana Šlamberová, Richard Rokyta |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Motor Activity Methamphetamine Homing Behavior Developmental Neuroscience Pregnancy Internal medicine Lactation Reflex medicine Animals Cross-fostering Rats Wistar Maternal Behavior Postural Balance Prenatal methamphetamine exposure Analysis of Variance Body Weight medicine.disease Rats medicine.anatomical_structure Endocrinology Prenatal stress Prenatal Exposure Delayed Effects Gestation Female Righting reflex Psychology Stress Psychological Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 27:149-155 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2008.11.006 |
| Popis: | There are studies showing that drug abuse during pregnancy may have a long-term effect on progeny of drug-abusing mothers. Our previous work demonstrated that prenatal and/or postnatal methamphetamine injections impair maternal behavior. The purpose of the present study was to assess the effect of prenatal methamphetamine or stress exposure and postnatal breeding on postnatal development of rat pups. Female rats were injected with methamphetamine (5 mg/kg daily) or physiological saline prior, during and after gestation. Absolute controls did not receive any injections. On postnatal day 1, pups were cross-fostered so that each mother received some of her own and some of the pups from the mothers with the other two treatments. Pups were weighted daily for the entire lactation period. Postural motor reaction development was examined daily by righting reflex between postnatal day 1 and 12. On postnatal day 15 homing test examining pups' nest-seeking behavior was performed. On postnatal day 23 rotarod and bar-holding tests were used to investigate sensorimotor coordination of pups. We demonstrated that prenatal methamphetamine exposure impairs performance of sensorimotor tests (righting reflex on surface and rotarod test). Moreover, the effect of methamphetamine as well as the effect of prenatal stress induced by saline injections was affected by postnatal breeding conditions in sensorimotor tests as well as in the test of homing. Our results support the hypothesis that the variation in rat maternal care could serve as a mechanism for a nongenomic behavioral mode of transmission of traits. |
| Databáze: | OpenAIRE |
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