Nucleoside reverse transcriptase inhibitors are able and protease inhibitors unable to induce the tolerogenic molecule HLA-G1 on monocytes from HIV-1 infected patients
Autor: | R. González, G. García-Jurado, José Manuel Lozano, Angela Camacho, Antonio Rivero, J. Peña, J. Torres-Cisneros |
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Rok vydání: | 2006 |
Předmět: |
Adult
Male medicine.medical_treatment CD14 Immunology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Monocytes Nucleoside Reverse Transcriptase Inhibitor Acquired immunodeficiency syndrome (AIDS) immune system diseases HLA Antigens HLA-G medicine Immune Tolerance Immunology and Allergy Humans Protease Inhibitors Drug toxicity Aged HLA-G Antigens Protease business.industry Histocompatibility Antigens Class I virus diseases Nucleosides General Medicine Middle Aged medicine.disease Virology Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors HIV-1 Reverse Transcriptase Inhibitors Female business |
Zdroj: | Human immunology. 68(4) |
ISSN: | 0198-8859 |
Popis: | Our group has previously reported that a significantly larger proportion of peripheral monocytes from human immunodeficiency virus type 1 (HIV-1) seropositive individuals receiving highly active antiretroviral therapy (HAART) express HLA-G1 [ 1 ] and also that one of the HAART components, the nucleoside reverse transcriptase inhibitors (NRTIs), may be involved in this effect [ 2 ]. Because protease inhibitors (PIs) are another component of HAART that are administered with NRTIs, the aim of this work was to determine whether or not PIs are also involved in the HLA-G1 changes previously observed in treated HIV-1 positive patients. CD14+ cells expressing HLA-G1 were therefore measured in 7 HIV-1 positive patients whose initial HAART was changed to a protease inhibitor–only regime due to drug toxicity and/or virologic resistance. Our results indicate that PIs do not appear to be implicated in the rise of HLA-G1 expression on CD14+ cells from HIV-1 infected individuals receiving HAART, while we further confirm that NRTIs are involved in the surface induction of HLA-G1. |
Databáze: | OpenAIRE |
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