A population-based study identifies an association of THBS2 with intervertebral disc degeneration
| Autor: | Masatoshi Teraguchi, Hiroshi Hashizume, Hiroshi Yamada, Shiro Ikegawa, Munehito Yoshida, Tsuyoshi Deguchi, Noriko Yoshimura, Toru Akune, Shu Tanaka, Masahiro Nakajima, M. Nojima |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Population Biomedical Engineering Single-nucleotide polymorphism Intervertebral Disc Degeneration Degeneration (medical) Logistic regression Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Japan Rheumatology Internal medicine medicine Humans Orthopedics and Sports Medicine education Association (psychology) Aged Aged 80 and over 030203 arthritis & rheumatology education.field_of_study business.industry Intervertebral disc Odds ratio Middle Aged Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Female Thrombospondins business Body mass index |
| Zdroj: | Osteoarthritis and Cartilage. 27:1501-1507 |
| ISSN: | 1063-4584 |
| Popis: | To clarify the genetic mechanisms underlying intervertebral disc degeneration (IDD), we examined the associations between single-nucleotide polymorphisms (SNPs) and indicated as coefficient of interaction term (IDD) in a general population in Japan.This was a cross-sectional study. In 1,605 participants, C2-3 to L5/S1 in the total spine magnetic resonance imaging (MRI) were evaluated using the Pfirrmann's scoring system. Disc scores of 4 and 5 were defined as IDD. Eight SNPs in eight genes associated with IDD were examined at each disc level, considering the non-genetic risk factors of age, sex, and body mass index (BMI).The highest odds ratio was found for rs9406328 in the THBS2 gene at disc level T12-L1 (OR 1.27, 95%CI 1.05 to 1.53), and this association was strengthened after adjustment for age using logistic regression (OR 1.37, 95%CI 1.12 to 1.67). Among participants aged50 years and 50-59, the average IDD score in those with 2 risk alleles of rs9406328 was markedly higher than in those with 0 or 1 risk allele, and the difference is much wider than the elderly participants. It indicates the genetic effect of rs9406328 is stronger in the younger age groups. Finally, multiple linear regression analyses of the association between rs9406328 and IDD, adjusted for age, sex, and BMI at each disc level, showed a statistical interaction between age and the number of risk alleles at C7-T1, T3-4 and T4-T5 as well as T12-L1.CONCLUSION: The association between rs9406328 in THBS2 and IDD was replicated. The contributions of genetic and environmental factors to IDD differed by disc level. |
| Databáze: | OpenAIRE |
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