Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer
| Autor: | M. Snchez, A. Alvarez, M. G. Corte, M. Lamelas, Corte, Francisco J. Vizoso, M T Allende, M. Vijande, M. Bongera, J. Rodrguez, Luis O. González, J.L. Garca-Muiz, J. Vzquez |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Cathepsin D Breast Neoplasms Biology Pathology and Forensic Medicine Metastasis 03 medical and health sciences Cytosol 0302 clinical medicine Breast cancer medicine Humans Clinical significance Pathological Aged Aged 80 and over Immunoradiometric assay Protease Proteolytic enzymes Middle Aged Prognosis medicine.disease Survival Rate 030104 developmental biology Receptors Estrogen Oncology 030220 oncology & carcinogenesis Multivariate Analysis Cancer research Female Receptors Progesterone |
| Zdroj: | The International journal of biological markers. 20(2) |
| ISSN: | 1724-6008 |
| Popis: | Background Cathepsin D is the proteolytic enzyme most frequently implicated as a prognostic factor in primary breast cancer. In the present study we evaluated by means of an immunoradiometric assay the tumor content of this protease in primary breast cancer, its relationship with tumor-related clinical and pathological parameters, and its prognostic significance in a large series of breast cancer patients. Method The study comprised 1033 women with histologically established invasive breast cancer. Cathepsin D was measured in cytosol samples by means of an immunoradiometric assay to determine the total amount of cathepsin D (52 kDa, 48 kDa and 34 kDa). Evaluation of relapse-free survival and cause-specific survival was performed in the group of 1003 patients without evidence of metastasis at the time of initial diagnosis. The median follow-up of the patients who were free of recurrence was 54 months. Results Cathepsin D levels showed a wide range among the studied tumors (n=1033; median (range) 41 (0.9–2504) pmol/mg protein). Statistical analysis showed that the median cathepsin D levels were considerably higher in large tumors (T2–4) than in smaller ones (T1) (p=0.017), as well as in node-positive than in node-negative tumors (p=0.004). Cathepsin D levels were also higher in ductal tumors than in the other histological types (p=0.001), as well as in moderately or poorly differentiated tumors (p59 pmol/mg protein) were notably associated with a shorter cause-specific survival in the whole group of patients with breast cancer, as well as in the subgroup of node-positive patients (pConclusions This study suggests that elevated intratumoral cathepsin D levels may identify a subset of node-positive breast cancer patients showing a high probability of earlier death. |
| Databáze: | OpenAIRE |
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