Life-span exposure to sinusoidal-50 Hz magnetic field and acute low-dose γ radiation induce carcinogenic effects in Sprague-Dawley rats
Autor: | Fabiana Manservisi, Michelina Lauriola, Michela Padovani, Simona Panzacchi, Fiorella Belpoggi, Eva Tibaldi, Livio Giuliani, Morando Soffritti, Marco Manservigi, Luciano Bua, Laura Falcioni, David G. Hoel |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Aging Pathology medicine.medical_specialty Neoplasms Radiation-Induced Carcinogenesis Longevity Mammary gland Physiology Radiation Dosage medicine.disease_cause Risk Assessment Rats Sprague-Dawley 03 medical and health sciences Sex Factors 0302 clinical medicine Breast cancer medicine Animals Radiology Nuclear Medicine and imaging Carcinogen γ radiation Radiological and Ultrasound Technology business.industry Incidence (epidemiology) Cancer Dose-Response Relationship Radiation Environmental Exposure Environmental exposure medicine.disease Rats Magnetic Fields 030104 developmental biology medicine.anatomical_structure Gamma Rays 030220 oncology & carcinogenesis Female business Whole-Body Irradiation |
Zdroj: | International Journal of Radiation Biology. 92:202-214 |
ISSN: | 1362-3095 0955-3002 |
Popis: | Background In 2002 the International Agency for Research on Cancer classified extremely low frequency magnetic fields (ELFMF) as a possible carcinogen on the basis of epidemiological evidence. Experimental bioassays on rats and mice performed up to now on ELFMF alone or in association with known carcinogens have failed to provide conclusive confirmation. Objectives To study the carcinogenic effects of combined exposure to sinusoidal-50 Hz (S-50 Hz) magnetic fields and acute γ radiation in Sprague-Dawley rats. Methods We studied groups of male and female Sprague-Dawley rats exposed from prenatal life until natural death to 20 or 1000 μT S-50 Hz MF and also to 0.1 Gy γ radiation delivered as a single acute exposure at 6 weeks of age. Results The results of the study showed significant carcinogenic effects for the mammary gland in males and females and a significant increased incidence of malignant schwannomas of the heart as well as increased incidence of lymphomas/leukemias in males. Conclusions These results call for a re-evaluation of the safety of non-ionizing radiation. |
Databáze: | OpenAIRE |
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