In situ tissue regeneration using a warp-knitted fabric in the canine aorta and inferior vena cava†
| Autor: | Hayato Konishi, Atsuko Onishi, Kazuteru Kohno, Shintaro Nemoto, Yohei Sakamoto, Takahiro Katsumata, Ryo Shimada, Tatsuya Suzuki, Jun Sakurai, Masaya Ito, Hideaki Yamada |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Heart Defects
Congenital Pulmonary and Respiratory Medicine Polyesters Vena Cava Inferior 030204 cardiovascular system & hematology Inferior vena cava 03 medical and health sciences chemistry.chemical_compound Dogs 0302 clinical medicine Suture (anatomy) Tensile Strength medicine.artery Absorbable Implants Materials Testing medicine Animals Pericardium Polytetrafluoroethylene Aorta Bioprosthesis Guided Tissue Regeneration business.industry General Medicine medicine.disease Disease Models Animal medicine.anatomical_structure 030228 respiratory system chemistry medicine.vein Vasa vasorum Descending aorta cardiovascular system Gelatin Cattle Surgery Cardiology and Cardiovascular Medicine business Calcification Biomedical engineering |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 54:318-327 |
| ISSN: | 1873-734X 1010-7940 |
| Popis: | Objectives Materials used in paediatric cardiac surgery have drawbacks of deterioration, calcification and pseudointimal proliferation resulting in haemodynamic disturbance. The aim of this study was to investigate whether these drawbacks can be overcome by in situ tissue regeneration using a newly developed synthetic hybrid fabric (SHF). Methods The SHF is an expandable, warp-knitted fabric composed of a combination of biodegradable [poly-l-lactic acid (PLLA)] and non-biodegradable (polyethylene terephthalate) yarns. The fabric is coated with cross-linked gelatin. Mechanical properties of the SHF were compared with those of 2 commercial products: expanded polytetrafluoroethylene sheet and glutaraldehyde-treated bovine pericardium. An oval-shaped defect created in the canine descending aorta or inferior vena cava was filled with the SHF patch. After 2 weeks and 1, 3, 6 and 12 (or 24 in the inferior vena cava) months, the patch was removed for histological examination and evaluation of the remaining PLLA. Results The SHF exhibited satisfactory tensile and suture retention strength for surgical implantation similar to or better than the 2 commercial products. Tissue regeneration was induced with multilayered smooth muscle cells and collagen fibres on both sides of the patch, along with a mature endothelial layer and tissue connections containing vasa vasorum across the patch in the aorta and inferior vena cava. Inflammatory reactions were minimal, and no calcium deposition occurred. The molecular weight of PLLA was reduced to half at 12 months after implantation. Conclusions The SHF may solve the drawbacks of the existing products. Further studies of the expandability of the SHF patch after degradation of PLLA are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|