Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
| Autor: | Michael Detmar, Towia A. Libermann, Jay W. Shin, David R. Sage, Kimberly E. Foreman, Joyce D. Fingeroth, Young-Kwon Hong, Christine L. Curry, Satoshi Hirakawa, Bruce J. Dezube |
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| Rok vydání: | 2004 |
| Předmět: |
Endothelium
government.form_of_government Down-Regulation Biology medicine.disease_cause Virus Herpesviridae Downregulation and upregulation Genetics medicine Gammaherpesvirinae Cells Cultured Lymphatic Vessels Gene Expression Profiling virus diseases medicine.disease biology.organism_classification Lymphatic Endothelium medicine.anatomical_structure Lymphatic system Immunology Herpesvirus 8 Human government Cancer research Sarcoma |
| Zdroj: | Nature genetics. 36(7) |
| ISSN: | 1061-4036 |
| Popis: | Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes. |
| Databáze: | OpenAIRE |
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