Angiogenic factors for prediction of preeclampsia and intrauterine growth restriction onset in high-risk women: AngioPred study
| Autor: | Carole Prieux, Céline Chapelle, Silvy Laporte, Jean-Christophe Gris, Céline Chauleur, Tiphaine Raia-Barjat |
|---|---|
| Přispěvatelé: | Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Université Jean Monnet [Saint-Étienne] (UJM), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Groupe de recherche sur la thrombose (GRT (EA 3065)) |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty intrauterine growth restriction Pregnancy High-Risk Intrauterine growth restriction 030204 cardiovascular system & hematology Preeclampsia preeclampsia Cohort Studies 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Predictive Value of Tests Pregnancy medicine soluble fms-like tyrosine kinase-1 Humans Soluble endoglin reproductive and urinary physiology ComputingMilieux_MISCELLANEOUS 030219 obstetrics & reproductive medicine Angiogenic factors Fetal Growth Retardation Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology Plasma levels medicine.disease Prognosis Case-Control Studies Pediatrics Perinatology and Child Health Angiogenesis Inducing Agents Female Complication business soluble endoglin Soluble fms-like tyrosine kinase-1 [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Maternal Serum Screening Tests Cohort study |
| Zdroj: | Journal of Maternal-Fetal and Neonatal Medicine Journal of Maternal-Fetal and Neonatal Medicine, Taylor & Francis, 2017, pp.1--10. ⟨10.1080/14767058.2017.1378325⟩ |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2017.1378325⟩ |
| Popis: | The study aimed to compare the level of two angiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), for the prediction of preeclampsia and intrauterine growth restriction in high-risk pregnant women.A prospective multicenter cohort study of 200 pregnant patients was conducted between June 2008 and October 2010. sFlt1 and sEng were measured by enzyme-linked immunosorbent assay.Forty-five patients developed a placenta-mediated adverse pregnancy outcome. Plasma levels of sFlt1 and sEng were higher in patients who will experience a preeclampsia at 28, 32, and 36 weeks compared with patients with no complication. The same results were observed for intrauterine growth restriction. Plasma levels of sFlt1 and sEng were not significantly different for patients with preeclampsia compare to patients with intrauterine growth restriction. Patients with early pre-eclampsia (PE) had very high rates of angiogenic factors at 20, 24, and 28 weeks. Patients with late PE and early and late intrauterine growth retardation (IUGR) had high rates at 32 and 36 weeks.In high-risk women, angiogenic factors are disturbed before the onset of preeclampsia and this is true for intrauterine growth restriction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|