| Autor: |
Marja-Liisa Lokki, C. Yung Yu, László Romics, Erwin K. Chung, Yan Yang, Sigurdur Bödvarsson, Jenõ Duba, Csaba Szalai, Gudmundur Thorgeirsson, Ágnes Vatay, Bi Zhou, Judith Kramer, Margit Kovács, Gudmundur J. Arason, Carol A. Blanchong, István Karádi, Zoltán Prohászka, George Füst |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
International Immunology. 16:1507-1514 |
| ISSN: |
1460-2377 |
| Popis: |
The genetic basis for addiction to tobacco smoking--particularly that of the perception of olfactory stimuli that may be important in reinforcing smoking addiction--is largely unknown. A cluster of genes for olfactory receptors is in close proximity to the MHC region on chromosome 6. Polymorphisms of MHC class III genes (RCCX modules, TNFA promoter polymorphisms) were determined in 101 healthy subjects and 232 coronary artery disease (CAD) patients from Hungary with defined tobacco smoking habits. A highly significant association between ever smoking (past + current smokers) and a specific MHC haplotype was observed (odds ratios = 2.14-4.13; P-values = 0.012 to |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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