Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge
| Autor: | Ian D. Robertson, I.C. Cheng, John Edwards, M.C. Lee, Y.F. Sun, Trevor M. Ellis, S.P. Chen, Ming-Hwa Jong, P.C. Yang, Y.L. Lin |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Swine
Taiwan Viral Nonstructural Proteins Antibodies Viral Virus Disease Outbreaks Immune system Neutralization Tests medicine Animals Neutralizing antibody Swine Diseases Viral Structural Proteins General Veterinary General Immunology and Microbiology biology Foot-and-mouth disease Vaccination Public Health Environmental and Occupational Health Viral Vaccines medicine.disease Virology Titer Infectious Diseases Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Immunology biology.protein Molecular Medicine Emulsions Viral disease Antibody |
| Zdroj: | Vaccine. 25:4464-4469 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2007.03.019 |
| Popis: | The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2-4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 3B NSP antibody ELISA after vaccination, the mean S/P ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points. |
| Databáze: | OpenAIRE |
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