Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans

O-->7',4 beta-->8')-epicatechin-3'-O-gallate (8), together with (-)-epicatechin-3-O-gallate (4), (-)-epigallocatechin (5), (-)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4 alpha-->8')-epigallocatechin (7), were isolated from the tea plant Camellia sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially available pyrogallol (1), (+)-catechin (2), and (-)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 approximately 6, 9, 4, 5, 1. The LC(50) (96 h) values of 8 and 9 were evaluated as 49 and 334 micromol L(-1), respectively. These data show that many green tea polyphenols may be potential anthelmintics. -->

ISSN:	1861-0293
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68580f8a919bc7fcaac5885852a4246 https://pubmed.ncbi.nlm.nih.gov/18404315
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....a68580f8a919bc7fcaac5885852a4246
Autor:	Noriko Matsuda, Daisuke Mukai, Masashi Sato, Yu Yoshioka, Toru Yamasaki
Rok vydání:	2007
Předmět:	Mebendazole Camellia sinensis Catechin chemistry.chemical_compound Phenols medicine Tannin Animals Anthelmintic Caenorhabditis elegans chemistry.chemical_classification Flavonoids biology Traditional medicine Tea Plant Extracts Antinematodal Agents Polyphenols biology.organism_classification Plant Leaves chemistry Pyrogallol Polyphenol Toxicity Molecular Medicine medicine.drug
Zdroj:	Journal of natural medicines. 62(2)
ISSN:	1861-0293
Popis:	A novel gallate of tannin, (-)-epigallocatechin-(2 beta-->O-->7',4 beta-->8')-epicatechin-3'-O-gallate (8), together with (-)-epicatechin-3-O-gallate (4), (-)-epigallocatechin (5), (-)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4 alpha-->8')-epigallocatechin (7), were isolated from the tea plant Camellia sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially available pyrogallol (1), (+)-catechin (2), and (-)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 approximately 6, 9, 4, 5, 1. The LC(50) (96 h) values of 8 and 9 were evaluated as 49 and 334 micromol L(-1), respectively. These data show that many green tea polyphenols may be potential anthelmintics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68580f8a919bc7fcaac5885852a4246 https://pubmed.ncbi.nlm.nih.gov/18404315 Zobrazit plný text záznamu Full text from SpringerLink