Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
| Autor: | Sabina, Resic-Lindehammer, K, Larsson, E, Ortqvist, A, Carlsson, E, Cederwall, C M, Cilio, S-A, Ivarsson, B A, Jönsson, H E, Larsson, K, Lynch, J, Neiderud, A, Nilsson, S, Sjöblad, A, Lernmark, M, Aili, L E, Bååth, E, Carlsson, H, Edenwall, G, Forsander, B W, Granstro, I, Gustavsson, R, Hanås, L, Hellenberg, H, Hellgren, E, Holmberg, H, Hörnell, Sten-A, Ivarsson, C, Johansson, G, Jonsell, K, Kockum, B, Lindblad, A, Lindh, J, Ludvigsson, U, Myrdal, K, Segnestam, L, Skogsberg, L, Strömberg, U, Ståhle, B, Thalme, K, Tullus, T, Tuvemo, M, Wallensteen, O, Westphal, J, Aman |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Adolescent Genotype Endocrinology Diabetes and Metabolism Human leukocyte antigen HLA-DQ alpha-Chains law.invention Endocrinology Gene Frequency HLA Antigens law HLA-DQ Antigens Diabetes mellitus HLA-DQ Internal Medicine medicine HLA-DQ beta-Chains Humans Age of Onset Allele Child Polymerase chain reaction Sweden Autoimmune disease Type 1 diabetes business.industry Infant General Medicine medicine.disease Diabetes Mellitus Type 1 Child Preschool Immunology Female business |
| Zdroj: | Acta Diabetologica. 45:231-235 |
| ISSN: | 1432-5233 0940-5429 |
| Popis: | The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk. |
| Databáze: | OpenAIRE |
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