Dixon imaging-based partial volume correction improves quantification of choline detected by breast 3D-MRSI
| Autor: | Wolfgang Bogner, Pascal A. T. Baltzer, Marek Chmelik, Siegfried Trattnig, Lenka Minarikova, Katja Pinker-Domenig, Stephan Gruber, Thomas H. Helbich |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Body water Partial volume Breast Neoplasms computer.software_genre Signal Imaging phantom Choline Breast cancer Imaging Three-Dimensional Body Water Voxel medicine Humans Radiology Nuclear Medicine and imaging Breast Reproducibility business.industry Phantoms Imaging Ultrasound Reproducibility of Results General Medicine Organ Size Middle Aged medicine.disease Magnetic Resonance Imaging Adipose Tissue Female Radiology business Nuclear medicine computer |
| Zdroj: | European radiology. 25(3) |
| ISSN: | 1432-1084 |
| Popis: | Our aim was to develop a partial volume (PV) correction method of choline (Cho) signals detected by breast 3D-magnetic resonance spectroscopic imaging (3D-MRSI), using information from water/fat-Dixon MRI. Following institutional review board approval, five breast cancer patients were measured at 3 T. 3D-MRSI (1 cm3 resolution, duration ~11 min) and Dixon MRI (1 mm3, ~2 min) were measured in vivo and in phantoms. Glandular/lesion tissue was segmented from water/fat-Dixon MRI and transformed to match the resolution of 3D-MRSI. The resulting PV values were used to correct Cho signals. Our method was validated on a two-compartment phantom (choline/water and oil). PV values were correlated with the spectroscopic water signal. Cho signal variability, caused by partial-water/fat content, was tested in 3D-MRSI voxels located in/near malignant lesions. Phantom measurements showed good correlation (r = 0.99) with quantified 3D-MRSI water signals, and better homogeneity after correction. The dependence of the quantified Cho signal on the water/fat voxel composition was significantly (p |
| Databáze: | OpenAIRE |
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