MEMS Fabricated Chip for an Implantable Drug Delivery Device
| Autor: | Zouhair Sbiaa |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Silicon
Biosensing Techniques Drug Delivery Systems Microcomputers In vivo Oral administration Materials Testing Humans Technology Pharmaceutical Medicine Patient compliance Implanted device Drug Implants Microelectromechanical systems Miniaturization business.industry Equipment Design Infusion Pumps Implantable Chip Kinetics Catheter Drug delivery Leuprolide Peptides business Biomedical engineering |
| Zdroj: | EMBC |
| DOI: | 10.1109/iembs.2006.260534 |
| Popis: | � Abstract— We present a silicon-based implantable drug delivery system (IDDS) for the administration of compounds in vivo. The implanted device contains the drug-filled silicon microchip, control circuitry, telemetry capability, and a battery. At the heart of the IDDS is the drug-containing microchip, a MEMS (MicroElectroMechanical Systems)- based device. A process was developed for the fabrication of the silicon chip. MicroCHIPS' drug release technology has been successfully demonstrated in vitro and in vivo using the therapeutic peptide leuprolide as a model compound. I. INTRODUCTION While oral delivery is considered the preferred method of administering many drugs, additional methods employing pulmonary, infusion, and implantable systems have been developed to overcome drug delivery constraints. For example, many macromolecules are either digested in the gastrointestinal tract or are not well absorbed into the bloodstream. Oral administration may also not be appropriate for drugs that require a rapid onset of action(1). Similarly, pulmonary systems such as inhalers require drugs to be absorbed into the bloodstream from the lungs. Drug delivery by injection has other disadvantages. Patients must choose between traveling to a treatment site and maintaining a home supply. Furthermore, the discomfort of frequent injections leads to poor patient compliance. Some injection regimens are complicated to administer and may require a clinician's help. Portable infusion systems allow unassisted intravenous administration; however, these systems can only administer drugs in liquid form and require a transcutaneous catheter and an external pump. |
| Databáze: | OpenAIRE |
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