Genetic markers linked to neuronal ceroid lipofuscinosis in English setter dogs
| Autor: | A. N. Wilton, N. G. Holmes, R. K. Juneja, T. Aarskaug, L. Moe, M. Sletten, I. Bjerkås, Unni Grimholt, Francis Galibert, Frode Lingaas, Gaudenz Dolf |
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| Rok vydání: | 1998 |
| Předmět: |
Genetic Markers
Genetic Linkage Locus (genetics) Biology Aminopeptidases Polymerase Chain Reaction law.invention Dogs Gene mapping Species Specificity law Genetic linkage Neuronal Ceroid-Lipofuscinoses Endopeptidases Genetics medicine Animals Humans Inbreeding Dog Diseases Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Gene Polymerase chain reaction Polymorphism Single-Stranded Conformational DNA Primers Membrane Glycoproteins Base Sequence Tripeptidyl-Peptidase 1 Chromosome Mapping Proteins General Medicine medicine.disease Disease Models Animal CLN3 Genetic marker Animal Science and Zoology Neuronal ceroid lipofuscinosis Serine Proteases Molecular Chaperones Peptide Hydrolases |
| Zdroj: | Animal genetics. 29(5) |
| ISSN: | 0268-9146 |
| Popis: | The neuronal ceroid lipofuscinoses (NCL) are a group of fatal autosomal recessive neurodegenerative diseases occurring in human and some domesticated animal species. A canine form of the disease (CNCL) has been extensively studied in a Norwegian colony of inbred English setters since 1960. A resource family developed for genetic mapping and comprising 170 individuals was typed for 103 genetic markers. Linkage analysis showed three genetic markers to be linked to the disease locus with the closest marker at a distance of about 3 CM. Two other loci were linked with these markers making a linkage group of five genetic markers. The linkage group spanned a distance of 54 CM. Two genes for human forms of the disease, CLN2 and CLN3, have been identified and mapped to human chromosome 11p15 and 16p12, respectively. The present study did not indicate any linkage between CNCL and the canine CLN3 homologue or to homologues of markers for genes that map close to human CLN2. |
| Databáze: | OpenAIRE |
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