Rhodium-catalyzed and zinc(II)-triflate-promoted asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones

Autor:	Jacob R. Remacle, Dana L. T. Laird, Scott A. May, Joel R. Calvin, Michael O. Frederick
Rok vydání:	2012
Předmět:	Mesylates Molecular Structure Organic Chemistry Asymmetric hydrogenation chemistry.chemical_element Stereoisomerism Zinc Ketones Ligands Biochemistry Medicinal chemistry Catalysis Rhodium chemistry Molecule Epimer Hydrogenation Physical and Theoretical Chemistry Trifluoromethanesulfonate
Zdroj:	Organic letters. 14(4)
ISSN:	1523-7052
Popis:	The asymmetric hydrogenation of tetrasubstituted α,β-unsaturated ketones has been accomplished using an in situ formed rhodium-Josiphos catalyst. The reaction is enhanced by addition of catalytic zinc(II) triflate, which significantly improves turnover frequency while suppressing epimerization of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681430cb5ec0420a9534d36c2b0cfba https://pubmed.ncbi.nlm.nih.gov/22288716 Zobrazit plný text záznamu