Imbalance of Interleukin-18 and Interleukin-18 Binding Protein in Children with Henoch-Schönlein Purpura
| Autor: | Yajuan Wang, Xiong Zou, Yutong Gao, Cunfu Wang, Yong Zhang, D E Wei, O Chen, N N Shan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Henoch-Schonlein purpura IgA Vasculitis Endogeny Biochemistry Peripheral blood mononuclear cell Proinflammatory cytokine Internal medicine medicine Humans RNA Messenger Child Regulation of gene expression business.industry Binding protein Remission Induction Biochemistry (medical) Interleukin-18 Antagonist Cell Biology General Medicine medicine.disease Endocrinology Gene Expression Regulation Case-Control Studies Child Preschool Intercellular Signaling Peptides and Proteins Female Interleukin 18 business |
| Zdroj: | Journal of International Medical Research. 39:2201-2208 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323001103900616 |
| Popis: | The balance between interleukin-18 (IL-18) and its endogenous antagonist, IL-18 binding protein (IL-18BP), was evaluated in children with Henoch-Schönlein purpura (HSP). Plasma IL-18 and IL-18BP levels and peripheral blood mononuclear cell IL-18 mRNA expression were significantly higher in patients with active HSP ( n = 30) than in healthy controls ( n = 20); IL-18BP mRNA expression was similar in active HSP and controls. Plasma levels and mRNA expression of IL-18 and IL-18BP in patients in remission ( n = 19) were similar to those in controls. The ratios of IL-18 / IL-18BP plasma levels and IL-18 / IL-18BP mRNA levels in active HSP were significantly higher than in patients in remission and healthy controls. Thus, adequate IL-18BP to block the proinflammatory activity of IL-18 may not be present in active HSP and regulation of the IL-18 / IL-18BP balance might provide a potential therapeutic strategy. |
| Databáze: | OpenAIRE |
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