Micro-macro link in rheology of erythrocyte and vesicle suspensions
| Autor: | Thomas Podgorski, Benoit Polack, Chaouqi Misbah, Maud-Alix Mader, Victoria Vitkova |
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| Přispěvatelé: | Laboratoire de Spectrométrie Physique (LSP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Georgi Nadjakov Institute of Solid State Physics, TheREx, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Financial support from CNES and ANR (MOSICOB project), CHU Grenoble |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Microscopy
[SDV.BIO]Life Sciences [q-bio]/Biotechnology Erythrocytes Biophysical Letters Intrinsic viscosity MESH: Unilamellar Liposomes MESH: Viscosity Analytical chemistry Biophysics Diagnostic tools 01 natural sciences 010305 fluids & plasmas Suspension (chemistry) Viscosity Rheology Suspensions MESH: Rheology 0103 physical sciences Humans [INFO.INFO-BT]Computer Science [cs]/Biotechnology 010306 general physics Unilamellar Liposomes Microscopy MESH: Humans Chemistry MESH: Erythrocytes Vesicle Blood flow MESH: Suspensions Hemorheology |
| Zdroj: | Biophysical Journal Biophysical Journal, Biophysical Society, 2008, 95 (6), pp.L33-5. ⟨10.1529/biophysj.108.138826⟩ |
| ISSN: | 1542-0086 0006-3495 |
| DOI: | 10.1529/biophysj.108.138826⟩ |
| Popis: | International audience; We report on the rheology of dilute suspensions of red blood cells (RBC) and vesicles. The viscosity of RBC suspensions reveals a previously unknown signature: it exhibits a pronounced minimum when the viscosity of the ambient medium is close to the value at which the transition from tank-treading to tumbling occurs. This bifurcation is triggered by varying the viscosity of the ambient fluid. It is found that the intrinsic viscosity of the suspension varies by about a factor of 4 in the explored parameter range. Surprisingly, this significant change of the intrinsic viscosity is revealed even at low hematocrit (5%). We suggest that this finding may be used to detect blood flow disorders linked to pathologies that affect RBC shape and mechanical properties. This opens future perspectives on setting up new diagnostic tools, with great efficiency even at very low hematocrit. Investigations are also performed on giant vesicle suspensions, and compared to RBCs. |
| Databáze: | OpenAIRE |
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