Biodistribution and tumour localisation of 131I SWA11 recognising the cluster w4 antigen in patients with small cell lung cancer
| Autor: | Peter J. Ell, R. Waibel, R. A. Stahel, Jonathan A. Ledermann, N. J. Marston, J. R. Buscombe |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Biodistribution Pathology medicine.medical_specialty Lung Neoplasms Time Factors medicine.drug_class Spleen Biology Monoclonal antibody digestive system Iodine Radioisotopes Antigen Antigens Neoplasm Bone Marrow medicine Carcinoma Humans Tissue Distribution Carcinoma Small Cell Radionuclide Imaging Respiratory disease Antibodies Monoclonal Biological Transport medicine.disease medicine.anatomical_structure Liver Oncology Antigens Surface biology.protein Bone marrow Antibody Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1993.297 |
| Popis: | The biodistribution of radiolabelled SWA11, a mouse monoclonal antibody recognising the cluster w4 group antigen associated with small cell lung cancer (SCLC) was studied in patients with SCLC. Five patients were injected intravenously with approximately 5 mCi of 131I conjugated to 1 mg of SWA11. The half-life of the radiolabel in blood was short but there was a prolonged second phase of clearance with a half-life of about 40 h. Tumour was detected by gamma camera imaging two patients. However, most of the whole body radioactivity was located in the bone marrow. At least 35% of the radioactivity in blood 18 h after injection was bound to circulating granulocytes and this probably accounted for the unusual biodistribution of the radiolabel in man. This study shows that the biodistribution of radiolabelled SWA11 in man differs from human tumour xenograft models and that the antibody in unsuitable for targeting therapy to SCLC in man. Images Figure 2 |
| Databáze: | OpenAIRE |
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