Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126

Autor: Albertinka J. Murk, Edwin M. Foekema, Charlotte Deerenberg
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Embryo
Nonmammalian
Time Factors
marine environment
Zygote
Health
Toxicology and Mutagenesis
Toxicology
impurities
Flatfish
dibenzo-p-dioxins
polychloorbifenylen
dioxins
life cycle
aquatische ecosystemen
media_common
Larva
biology
Soleá
Ecology
dr-calux(r) bioassay
equivalency factors
polychlorinated-biphenyls
Lipids
Wageningen Marine Research
fish stocks
solea
Flatfishes
polychlorinated biphenyls
larven
media_common.quotation_subject
Marine Biology
larvae
Aquatic Science
visstand
dioxinen
ecotoxicology
Lethal Dose 50
Animal science
in-vitro bioassay
Toxicity Tests
tong (vis)
Animals
Ecotoxicology
Metamorphosis
dover soles
marien milieu
Toxicologie
aquatic ecosystems
fish
Persistent organic pollutant
polyhalogenated aromatic-hydrocarbons
ecotoxicologie
biology.organism_classification
Soleidae
Survival Analysis
Acute toxicity
sediment extracts
life stages
flounder platichthys-flesus
levenscyclus
Water Pollutants
Chemical
verontreinigingen
Zdroj: Aquatic Toxicology, 90(3), 197-203
Aquatic Toxicology 90 (2008) 3
ISSN: 0166-445X
DOI: 10.1016/j.aquatox.2008.08.015
Popis: The effect of the dioxin-like PCB 126 (3,3¿,4,4¿,5-pentachlorobiphenyl) on the early development of the marine flatfish sole (Solea solea) was tested in a newly developed early life stage (ELS) test that includes the metamorphosis of the symmetric larvae into an asymmetrical flatfish. Early life stages of sole were exposed to a concentration series of PCB 126 in seawater until 4, 8, 10 and 15 days post fertilisation (dpf). Subsequently the development of the larvae was registered under further unexposed conditions. The LC50s at the start of the free-feeding stage (12 dpf) ranged between 39 and 83 ng PCB 126/l depending on exposure duration. After the fish had completed the metamorphosis, the LC50 values ranged between 1.7 and 3.7 ng PCB 126/l for the groups exposed for 4, 8 and 10 dpf, respectively. Thus exposure for only 4 days, covering only the egg stage, was sufficient to cause adverse effects during a critical developmental phase two weeks later. The internal dosages of these larvae, determined by means of an in vitro gene reporter assay as dioxin-equivalent values (TEQ), revealed a LD50 of 1 ng TEQ/g lipid, which is within the same order of magnitude as TEQ levels found in fish from highly polluted areas. This study indicates that ELS fish tests that are terminated shortly after the fish becomes free-feeding, underestimate the toxic potential of compounds with low acute toxicity such as PCBs. Our prolonged ELS with this native marine flatfish suggests that reproductive success of fish populations at contaminated sites can be affected De standaardprocedure die moet vaststellen hoe giftig bepaalde stoffen voor vislarfjes zijn, heeft een blinde vlek. Dat ontdekten Wageningse biologen door proeven met pasgeboren tongetjes. Hun onderzoek geeft waarschijnlijk een aanvullende verklaring voor de achteruitgang van de visstand
Databáze: OpenAIRE
Externí odkaz: