A nontraditional role for water in the cytochrome c oxidase reaction
| Autor: | Hoa Gh, Jack A. Kornblatt |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Cytochrome
Stereochemistry Cytochrome a Group chemistry.chemical_element In Vitro Techniques Biochemistry Oxygen Electron Transport Electron Transport Complex IV Electron transfer Osmotic Pressure Osmotic pressure Cytochrome c oxidase Animals Semipermeable membrane Oxidase test biology Cytochrome c peroxidase Myocardium Water chemistry Models Chemical biology.protein Biophysics Solvents Cytochromes Cattle Oxidation-Reduction |
| Zdroj: | Biochemistry. 29(40) |
| ISSN: | 0006-2960 |
| Popis: | The passage of electrons through cytochrome c oxidase is directly related to the activity of water. Reducing the activity in a system containing reductant, oxygen, and cytochrome oxidase blocks electron transfer between reduced cytochrome a and oxidized cytochrome a3. The extent of the block is directly related to the osmotic pressure of the system, implying that the protein shell of the oxidase acts as a semipermeable membrane that excludes osmotic perturbants but not water. It appears that approximately 10 water molecules must enter and leave the oxidase in order for internal electron transfer to occur. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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