| Popis: |
In view of the potency-enhancing effect of methyl substitution of the piperidine ring of the 4-phenylpiperidine analgesics and (he alkylene chain of the acyclic basic anilide analgesics, the 1-methyl, 1-benzyl, and 1-phenylethyl derivatives of 2-methyl-, 3-methyl-, and 2,5-dimethyl-4-propananilidopiperidine were prepared. The analgesic activity of these compounds indicates that 3- methylation has the greatest effect in enhancing analgesjc potency whereas 2-methyl and 2,5-dimethyl substitution is detrimental to analgesic activity. |
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