Effects of Hydrochlorothiazide on Water, Cation, and Norepinephrine Contents of Cardiovascular Tissues of Renovascular Hypertensive Dogs
| Autor: | Detlev Ganten, Ursula Ganten, Roger Boucher, Jacques Genest, J. M. Rojo-Ortega, George Constantopoulos, Miyako Kusumoto |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Epinephrine Aorta Thoracic Blood Pressure Blood volume Hematocrit Plasma renin activity General Biochemistry Genetics and Molecular Biology Norepinephrine (medication) Dogs Hydrochlorothiazide Internal medicine Renin Renin–angiotensin system medicine Animals Magnesium Mesenteric arteries Blood Volume medicine.diagnostic_test Chemistry Myocardium Sodium Water Arteries Mesenteric Arteries Femoral Artery Carotid Arteries Endocrinology Blood pressure medicine.anatomical_structure Potassium Calcium medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 147:769-774 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-147-38435 |
| Popis: | SummaryThirty adult male mongrel dogs were subjected to unilateral renal artery constriction and a week later to contralateral nephrec-tomy. Four weeks after the second operation, 25 animals had developed hypertension. Six of them (Group I) received hydrochlorothiazide (3.75 mg/kg/day, in two doses) orally for 6 weeks; a further six (Group II) were treated similarly but received KC1 (45 mg/kg/day, in two doses) in addition; the remaining 13 animals served as controls. Mean arterial blood pressure, recorded weekly, decreased by about 30 mm Hg (4 KPa) in both treated groups. Plasma potassium also declined significantly in both groups. Plasma renin activity was increased, but significantly only in group I, which also showed decreased blood and plasma volumes. Arterial water, sodium, and potassium were in general lower in groups I and II; the decrease in sodium was more consistent in arteries of group I. The norepinephrine content of arteries from the treated groups was not significantly different from that i... |
| Databáze: | OpenAIRE |
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