α1 - Antitrypsin Levels Predict Mortality from Ethionine-Induced Pancreatitis in Mice
| Autor: | Deren J, Abrams W, Conn Mi, Weinbaum G, Kueppers F |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Immunodiffusion medicine.medical_specialty Ratón Endocrinology Diabetes and Metabolism Alpha (ethology) Male mice Mice Inbred Strains Mice chemistry.chemical_compound Sex Factors Endocrinology Internal medicine Internal Medicine medicine Animals Choline Ethionine Serum Albumin Mice Inbred ICR Hepatology business.industry Albumin Blood Proteins medicine.disease Choline Deficiency α1 antitrypsin Pancreatitis chemistry alpha 1-Antitrypsin Female business |
| Zdroj: | Pancreas. 4:724-732 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-198912000-00011 |
| Popis: | Experimental pancreatitis can be induced by an ethionine-containing, choline-deficient diet in mice. We investigated the role of circulating alpha 1-antitrypsin in this model using two strains of mice: ICR and C57BL-6. A 50% reduction in circulating alpha 1-antitrypsin occurred in all mice by day three of diet exposure. Total protein was reduced by only 9% and albumin was unchanged. Female mice of both strains had significantly lower alpha 1-antitrypsin levels than male mice prior to and after diet exposure. This was associated with significantly greater mortality in both female strains. Interstrain comparisons showed a significantly higher mortality in the C57BL-6 females (100%) compared to the ICR females (58%); this corresponded to significantly lower alpha 1-antitrypsin levels in C57BL-6 females. Regardless of sex or strain, alpha 1-antitrypsin levels prior to and after diet exposure were significantly higher in mice surviving than in mice dying. We conclude that circulating alpha 1-antitrypsin is a predictor of mortality from diet-induced pancreatitis. |
| Databáze: | OpenAIRE |
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