Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain
Autor: | Jin Soo Ko, Yong Hun Jung, Jae Hyuk Do, Young Cheol Woo, Hyun Kang, Jun Mo Lee, Geun Joo Choi, Chong Wha Baek |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_treatment
Intraperitoneal injection Pain Propentofylline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology Mecamylamine Prazosin Animals Pain Management Medicine Dexmedetomidine Experimental Research Articles Pain Postoperative business.industry Rats Yohimbine Anesthesiology and Pain Medicine chemistry Hyperalgesia Anesthesia Systemic administration medicine.symptom business Acute pain Injections Intraperitoneal 030217 neurology & neurosurgery medicine.drug |
Zdroj: | The Korean Journal of Pain |
ISSN: | 2093-0569 2005-9159 |
Popis: | Background In this study, we sought to evaluate whether systemic propentofylline (PPF) has antiallodynic effects in a rat model of postoperative pain, and to assess the mechanism involved. Methods After plantar incision, rats were intraperitoneally injected with various doses of PPF to evaluate its antiallodynic effect. To investigate the involved mechanism, rats were intraperitoneally injected with yohimbine, dexmedetomidine, prazosin, naloxone, atropine or mecamylamine, following the incision of the rat hind paws, and then PPF was administered intraperitoneally. The mechanical withdrawal threshold (MWT) was evaluated using von Frey filaments at various time points and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were measured to determine the inflammatory response level. Results MWT was significantly increased after intraperitoneal injection of 30 mg/kg of PPF when compared with the control group. Injection of PPF and yohimbine, atropine or mecamylamine showed significant decreases in the MWT, while injection of PPF and dexmedetomidine showed a significant increase. Systemic administration of PPF inhibited the post-incisional increase in serum level of TNF-α and IL-1β. Conclusions Systemic administration of PPF following surgery presented antiallodynic effects in a rat model of postoperative pain. The antiallodynic effects against mechanical allodynia could be mediated by α-adrenergic and cholinergic receptors. |
Databáze: | OpenAIRE |
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