A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases

Autor: Deepak Shilkar, Venkatesan Jayaprakash, Biswatrish Sarkar, Barij Nayan Sinha, Sheikh Murtuja
Rok vydání: 2021
Předmět:
NMR
Nuclear magnetic resonance
viruses
medicine.medical_treatment
Clinical Biochemistry
Pharmaceutical Science
Dengue virus
medicine.disease_cause
Biochemistry
Dengue fever
Drug Discovery
YFV
Yellow fever virus
Coronavirus 3C Proteases
Chemistry
SARS
Severe acute respiratory syndrome-coronavirus
SI
Selectivity index
DHF
Dengue hemorrhagic fever
Cysteine Endopeptidases
WNV
West Nile virus
Molecular Medicine
HTS
Dengue-COVID-19 co-infection
Proteases
Hepatitis C virus
JEV
Japanese encephalitis virus
DSS
Dengue shock syndrome
Antiviral Agents
Article
HIV
Human Immuno-deficiency Virus
Virus
medicine
Humans
Protease inhibitor (pharmacology)
Protease Inhibitors
NS2B-NS3-pro inhibitors
High-throughput virtual screening (HTVS)
Molecular Biology
Dengue vaccine
ORF
Open reading frames
Protease
SARS-CoV-2
HTVS
High-throughput virtual screening
Organic Chemistry
Dengue Virus
medicine.disease
Virology
HTS
High-throughput screening
peptidomimetics
HCV
Hepatitis C Virus
SLC
Split luciferase complementation
DENV
Dengue virus
Zdroj: Bioorganic & Medicinal Chemistry
ISSN: 1464-3391
Popis: Dengue remains a disease of significant concern, responsible for nearly half of all arthropod-borne disease cases across the globe. Due to the lack of potent and targeted therapeutics, palliative treatment and the adoption of preventive measures remain the only available options. Compounding the problem further, the failure of the only dengue vaccine, Dengvaxia®, also delivered a significant blow to any hopes for the treatment of dengue fever. However, the success of Human Immuno-deficiency Virus (HIV) and Hepatitis C Virus (HCV) protease inhibitors in the past have continued to encourage researchers to investigate other viral protease targets. Dengue virus (DENV) NS2B-NS3 protease is an attractive target partly due to its role in polyprotein processing and also for being the most conserved domain in the viral genome. During the early days of the COVID-19 pandemic, a few cases of Dengue-COVID 19 co-infection were reported. In this review, we compared the substrate-peptide residue preferences and the residues lining the sub-pockets of the proteases of these two viruses and analyzed the significance of this similarity. Also, we attempted to abridge the developments in anti-dengue drug discovery in the last six years (2015–2020), focusing on critical discoveries that influenced the research.
Databáze: OpenAIRE
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