Approach To Diagnosis And Treatment Of Familial Hyperlipidemia

Autor:	Kübra ÇERÇİ, İmge Bortay TEKİN, Seyit UYAR
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	General and Internal Medicine Familial hyperlipidemia heterozygous familial hyperlipidemia homozygous familial hyperlipidemia low-density lipoprotein receptor mutation Genel ve Dahili Tıp
Zdroj:	Volume: 3, Issue: 1 4-8 DAHUDER Medical Journal
ISSN:	2791-9250
Popis:	Familial hyperlipidemia (FH) is an autosomal dominant inherited disease characterized by genetic disorders with severe high blood cholesterol levels. There are two forms of the disease which are homozygous and heterozygous FH. FH cases are generally caused by hereditorial mutations in the LDL receptor (LDL-R) gene and less commonly in genes encoding apolipoprotein B (Apo B) and pro-protein convertase subtilisin/kexin 9 (PCSK9) proteins. The risk of early-onset coronary artery disease (CAD) in FH patients is 20 times higher than the normal population. Early diagnosis and treatment of FH will greatly reduce the morbidity and mortality associated with CAD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a674fb3c58b758375a58271851b22de7 https://dergipark.org.tr/tr/pub/dahudermj/issue/75649/1195167 Zobrazit plný text záznamu