Supplementary Table S1, S2, S3, S4 and Supplementary Figure legends from Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases

Autor: Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Rok vydání: 2023
DOI: 10.1158/1535-7163.22503057
Popis: Supplementary Table S1: Statistics of data collection and processing of AuroraB/INCENP in complex with BI 847325; Supplementary Table S2: Statistics of data collection and processing of MEK1 in complex with BI 847325; Supplementary Table S3: Statistics of data collection and processing of AuroraB/INCENP in complex with BI 811283; Supplementary Table S4: Pharmacokinetic parameters of BI 847325 in mice and humans. Human data from Schöffski et al (31).
Databáze: OpenAIRE