Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review
| Autor: | Debora Estadella, Veronica Quispe Yujra, Celina Tizuko Fujiyama Oshima, Victor Hugo Pereira da Silva, Milena de Barros Viana, Daniel Araki Ribeiro, Samuel Rangel Claudio |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA damage Health Toxicology and Mutagenesis 010501 environmental sciences Biology Bioinformatics medicine.disease_cause 01 natural sciences Toxicology Fluorides 03 medical and health sciences chemistry.chemical_compound medicine Humans Environmental Chemistry 0105 earth and related environmental sciences DNA General Medicine Cell cycle Pollution Oxidative Stress 030104 developmental biology chemistry Carcinogenesis Fluoride Oxidative stress Genotoxicity DNA Damage Mutagens |
| Zdroj: | Environmental Science and Pollution Research. 24:15254-15259 |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis. |
| Databáze: | OpenAIRE |
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