Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future
| Autor: | Kjell Öberg, Steven W. J. Lamberts |
|---|---|
| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 2016 |
| Předmět: |
Adenoma
Cancer Research medicine.medical_specialty Pituitary gland Endocrinology Diabetes and Metabolism Octreotide 030209 endocrinology & metabolism Antineoplastic Agents Lanreotide Peptides Cyclic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Stomach Neoplasms Internal medicine Acromegaly Intestinal Neoplasms medicine Humans business.industry medicine.disease Pasireotide Pancreatic Neoplasms Neuroendocrine Tumors medicine.anatomical_structure Somatostatin Oncology chemistry 030220 oncology & carcinogenesis Growth Hormone-Secreting Pituitary Adenoma business Carcinoid syndrome medicine.drug Hormone |
| Zdroj: | Endocrine-Related Cancer, 23(12), R551-R566. Bioscientifica Ltd |
| ISSN: | 1351-0088 |
| DOI: | 10.1530/erc-16-0151 |
| Popis: | Acromegaly is a hormonal disorder that arises when the pituitary gland secretes excess growth hormone (GH), which in turn stimulates a concomitant increase in serum insulin-like growth factor 1 (IGF-1) levels. Gastroenteropancreatic neuroendocrine tumours (GEP-NET) constitute a heterogeneous group of tumours that can secrete serotonin and a variety of peptide hormones that may cause characteristic symptoms known as carcinoid syndrome or other symptoms and hormonal hypersecretion syndromes depending on the tumour’s site of origin. Current medical therapy for the treatment of acromegaly and GEP-NET involves the administration of somatostatin analogues that effectively suppress excess hormone secretion. After its discovery in 1979, octreotide became the first synthetic biologically stable somatostatin analogue with a short-acting formulation of octreotide introduced into clinical practice in the late 1980s. Lanreotide, another somatostatin analogue, became available in the mid-1990s initially as a prolonged-release formulation administered every 10 or 14 days. Long-acting release formulations of both octreotide (Sandostatin LAR and Novartis) and lanreotide (Somatuline Autogel, Ipsen), based on microparticle and nanoparticle drug-delivery technologies, respectively, were later developed, which allowed for once-monthly administration and improved convenience. First-generation somatostatin analogues remain one of the cornerstones of medical therapy in the management of pituitary and GEP-NET hormone hypersecretion, with octreotide having the longest established efficacy and safety profile of the somatostatin analogue class. More recently, pasireotide (Signifor), a next-generation multireceptor-targeted somatostatin analogue, has emerged as an alternative therapeutic option for the treatment of acromegaly. This review summarizes the development and clinical success of somatostatin analogues. |
| Databáze: | OpenAIRE |
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