Levels of bimatoprost acid in the aqueous humour after bimatoprost treatment of patients with cataract
| Autor: | Andrew Acheampong, Chi Wah Yung, David F. Woodward, Larry A. Wheeler, Shailaja Valluri, Louis B. Cantor, Joni Hoop, Darrell WuDunn, Yara Catoira, Arnold Cortes |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
genetic structures medicine.medical_treatment Aqueous humor Cataract Extraction Placebo Cataract Cataract extraction Cloprostenol Aqueous Humor Cellular and Molecular Neuroscience chemistry.chemical_compound Double-Blind Method Ophthalmology medicine Humans Prospective Studies Latanoprost Antihypertensive Agents Bimatoprost Aqueous humour business.industry Cataract surgery Amides Lipids eye diseases Sensory Systems Extended Report chemistry sense organs business medicine.drug |
| Zdroj: | The British journal of ophthalmology. 91(5) |
| ISSN: | 0007-1161 |
| Popis: | Purpose: Determine the aqueous humour concentration of the acid hydrolysis products of bimatoprost and latanoprost after a single topical dose of bimatoprost 0.03% or latanoprost 0.005% in humans. Methods: Randomized, controlled, double-masked, prospective study. Forty-eight eyes of 48 patients scheduled for routine cataract surgery were randomized in an 8:2:2 ratio to treatment with a single 30-μL drop of bimatoprost 0.03%, latanoprost 0.005%, or placebo at 1, 3, 6, or 12 hours prior to the scheduled cataract surgery. Aqueous humour samples were withdrawn at the beginning of the surgical procedure and analyzed using HPLC-tandem mass spectrometry. Results: Bimatoprost acid (17-phenyl trinor PGF2& [alpha]) was detected in aqueous samples at a mean concentration of 5.0 nM at hour 1, 6.7 nM at hour 3, and 1.9 nM at hour 6 after bimatoprost treatment. After latanoprost treatment, the mean concentration of latanoprost acid (13,14-dihydro-17-phenyl trinor PGF2& [alpha]) in aqueous samples was 29.1 nM at hour 1, 41.3 nM at hour 3, and 2.5 nM at hour 6. Acid metabolites were below the limit of quantitation in all samples taken 12 hours after dosing and in all samples from placebo-treated patients. None of the samples from latanoprost-treated patients contained quantifiable levels of nonmetabolized latanoprost. Nonmetabolized bimatoprost was detected in aqueous samples at a mean concentration of 6.6 nM at hour 1 and 2.4 nM at hour 3 after bimatoprost treatment. Conclusions: Low levels of bimatoprost acid were detected in aqueous humour samples from cataract patients treated with a single dose of bimatoprost. Latanoprost acid concentrations in samples from patients treated with latanoprost were at least 6-fold higher. These results suggest that bimatoprost acid in the aqueous humour does not sufficiently account for the ocular hypotensive efficacy of bimatoprost. |
| Databáze: | OpenAIRE |
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