The effects of sufentanil in the feline pulmonary vascular bed
| Autor: | James Phelps, Ikhlass N. Ibrahim, Syed R. Baber, Aaron M. Fields, Cuihua Zhang, Christopher Armstrong, Amir Baluch, Alan D. Kaye, Shane Huffman, Jason M. Hoover |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary Circulation
medicine.medical_specialty Sufentanil medicine.drug_class Narcotic Antagonists Vasodilator Agents Histamine Antagonists (+)-Naloxone Pulmonary Artery Histamine receptor Opioid receptor Internal medicine medicine Animals Lung Pharmacology Dose-Response Relationship Drug Naloxone business.industry Histaminergic medicine.disease Receptor antagonist Pulmonary hypertension Analgesics Opioid Vasodilation Diphenhydramine medicine.anatomical_structure Endocrinology Cats Vascular resistance Vascular Resistance business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 534:159-164 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2006.01.039 |
| Popis: | The purpose of this prospective vehicle controlled study was to test the hypothesis that sufentanil induces a depressor response in the pulmonary vascular bed of the cat and identify the receptors involved in the mediation or modulation of these effects. In separate experiments, the effects of diphenydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel blocker), L-N5-(1-Iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase (COX)-2 inhibitor), and naloxone (opiate receptor antagonist) were investigated on pulmonary arterial responses to sufentanil and other agonists in the feline pulmonary vascular bed. The lobar arterial perfusion pressures were continuously monitored, electronically averaged, and recorded. In the feline pulmonary vascular bed of the isolated left lower lobe, sufentanil induced a dose-dependent vasodepressor response that was not significantly altered after administration of glibenclamide, L-NIO, and nimesulide. However, the responses to sufentanil were significantly attenuated following administration of diphenhydramine and naloxone. The results of the present study suggest that sufentanil has potent vasodepressor activity in the pulmonary vascular bed of the cat and that this response may be mediated or modulated by both histaminergic and opioid receptor sensitive pathways. |
| Databáze: | OpenAIRE |
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