Nerve growth factor inhibits the expression of long-term potentiation in hippocampal slices
| Autor: | D'Arcangelo G, Mercanti D, Calissano P, Tancredi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Time Factors Neurite medicine.medical_treatment Submandibular Gland Wistar Pyramidal Tracts Hippocampus In Vitro Techniques Hippocampal formation Synaptic Transmission Settore BIO/09 Dose-Response Relationship Mice medicine Animals Nerve Growth Factors Rats Wistar Evoked Potentials Neuronal Plasticity Dose-Response Relationship Drug Chemistry General Neuroscience Growth factor Dentate gyrus Long-term potentiation Electric Stimulation Rats Nerve growth factor nervous system Synapses Synaptic plasticity Drug Neuroscience |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199302000-00008 |
| Popis: | Nerve growth factor and its receptor(s) are present in several parts of the hippocampus (CA1, CA3, dentate gyrus) but nothing is known about their function in this area which plays a fundamental role in learning and memory processes. NGF delivered exogenously to hippocampal slices causes a concentration-dependent, marked reduction in the expression (but not the induction) of long term potentiation (LTP) without altering basal synaptic transmission. The effect is already half maximal at 0.05-0.1 ng ml-1 NGF, is reversible after removal of this growth factor, and is also detectable with a modified version of NGF which has lost its neurite outgrowth promoting activity in PC12 cells. These findings point to a role for hippocampal NGF as a possible modulator of learning and memory processes. Such modulation would be mediated by high-affinity receptors functionally distinct from those promoting morphological differentiation of PC12 cells and other NGF target cells. |
| Databáze: | OpenAIRE |
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