The effects of rutaecarpine on the pharmacokinetics of acetaminophen in rats
| Autor: | Yurngdong Jahng, Hemin Jeong, Mi Jeong Kang, Sudeep R. Bista, Sangkyu Lee, Dong Hyeon Kim, Tae Cheon Jeong |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Cmax Pharmacology Indole Alkaloids Rats Sprague-Dawley Pharmacokinetics Cytochrome P-450 CYP1A2 Drug Discovery medicine Sprague dawley rats Animals Drug Interactions Acetaminophen biology Chemistry Alkaloid digestive oral and skin physiology Organic Chemistry Area under the curve Cytochrome P450 Rutaecarpine Rats Quinazolines biology.protein Cytochromes Molecular Medicine medicine.drug |
| Zdroj: | Archives of Pharmacal Research. 30:1629-1634 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02977334 |
| Popis: | Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study. When 25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the area under the curve of APAP in plasma was significantly decreased when compared to that of APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3 days, the % value of C(max) and area under the curve of acetaminophen-sulfate conjugate were significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of APAP in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink