A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate
| Autor: | Duncan McGeoch, Richard Sanders |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Transcription
Genetic Operon Mutant lac operon Lactose Coliphages Bacterial Proteins Transduction Genetic Escherichia coli Transcription factor Cyclic GMP Multidisciplinary biology Activator (genetics) Effector Structural gene Chromosome Mapping Molecular biology Galactosidases Biochemistry Genes Genetic Code Mutation biology.protein Biological Sciences: Genetics Catabolite activator protein |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 70(4) |
| ISSN: | 0027-8424 |
| Popis: | We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli . Genetic data have indicated that the suppressor of the P - mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3′:5′-cyclic GMP in addition to their normal effector, 3′:5′-cyclic AMP. |
| Databáze: | OpenAIRE |
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