New and Efficient Routes to Biomolecules Substituted with Cyclopentadienyltricarbonylrhenium and -Technetium Derivatives
| Autor: | Michèle Salmain, Franck Le Bideau, Gerard Jaouen, Siden Top |
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| Rok vydání: | 2001 |
| Předmět: |
Selective Estrogen Receptor Modulators
Technetium Tc 99m Sestamibi Chemistry Pharmaceutical Breast Neoplasms Cyclopentanes Octreotide Catalysis Structure-Activity Relationship Organometallic Compounds Moiety Organic chemistry Radioisotopes chemistry.chemical_classification Molecular Structure Chemistry Biomolecule Bioorganometallic chemistry Organic Chemistry Proteins Estrogens Organotechnetium Compounds General Chemistry Combinatorial chemistry Tamoxifen Rhenium Radiopharmaceuticals Peptides Half-Life |
| Zdroj: | Chemistry. 7:2289-2294 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/1521-3765(20010601)7:11<2289::aid-chem22890>3.0.co;2-r |
| Popis: | The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities of potential interest in the field of medicinal chemistry. However, the short half-life of useful radionuclides (186Re t1/2 = 3.7 d, 188Re t1/2 = 16.8 h, 99mTc t1/2 = 6 h), the risks inherent in their use, and their cost have led chemists to search for novel synthetic strategies that allow the rapid introduction of the [CpM(CO)3] moiety as a late step in the course of synthesizing the target molecule. The present paper describes different strategies recently reported in the literature to tackle this problem. |
| Databáze: | OpenAIRE |
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