The Novel Biomarker of Germ Cell Tumours, Micro-RNA-371a-3p, Has a Very Rapid Decay in Patients with Clinical Stage 1
Autor: | Raphael Ikogho, Johannes Hammel, Gazanfer Belge, Petra Anheuser, Christian Wülfing, Arlo Radtke, Finja Hennig, Klaus-Peter Dieckmann |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Urology 030232 urology & nephrology 03 medical and health sciences Young Adult 0302 clinical medicine Preoperative level Testicular Neoplasms Serum biomarkers microRNA Testis Biomarkers Tumor Medicine Humans In patient Stage (cooking) Original Paper business.industry Seminoma Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease MicroRNAs medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) business Orchiectomy Germ cell |
Zdroj: | Urologia internationalis. 100(4) |
ISSN: | 1423-0399 |
Popis: | Background: Accumulating evidence suggests serum levels of microRNA (miR)-371a-3p to be a novel tumour marker of testicular germ cell tumours (GCTs). Presently, there is only limited information regarding the velocity of decline of serum levels in response to treatment. Patients and Methods: Twenty-four patients with testicular GCT (20 seminoma, 4 nonseminoma, median age 40 years) with clinical stage 1 had measurements of serum levels of miR-371a-3p preoperatively and repeatedly on the following 3 days. Three had additional tests done within 24 h after surgery. Measurement results were analysed using descriptive statistical methods. Results: Serum levels dropped to 2.62, 1.27, and 0.47% of the preoperative level within 1, 2, and 3 days, respectively. The computed half-life amounts to 3.7–7 h. The velocity of decay is significantly associated with tumour size. Conclusions: Serum-levels of miR-371a-3p have a short half-life of less than 12 h. The rapid decay after treatment represents a valuable feature confirming the usefulness of miR-371a-3p as a valuable serum biomarker of GCT. |
Databáze: | OpenAIRE |
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