LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells
| Autor: | Lourdes Arriaga-Pizano, César López-Camarillo, Macrina B. Silva-Cázares, Nadia Flores-Huerta, Jessica L Prieto-Chávez |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
cancer stem cells lncRNAs lcsh:QR1-502 Breast Neoplasms Review Biology Biochemistry lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Cancer stem cell microRNA medicine Humans Epigenetics Molecular Biology therapy Cancer medicine.disease Phenotype microRNAs Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research Neoplastic Stem Cells Female RNA Long Noncoding Stem cell |
| Zdroj: | Biomolecules, Vol 11, Iss 380, p 380 (2021) Biomolecules |
| Popis: | Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC. |
| Databáze: | OpenAIRE |
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