Therapeutic approaches targeting cancer stem cells

Autor: Sai Ma, Pan Yunzhi, Kaiyue Cao, Sufang Zhou, Ming Li, Feng Qian, Aiqin Zhao, Chuan-wu Zhu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
cancer stem cells
Biomedical Research
medicine.medical_treatment
Antineoplastic Agents
medicine.disease_cause
lcsh:RC254-282
Epigenesis
Genetic
Metastasis
03 medical and health sciences
0302 clinical medicine
Cancer stem cell
Differentiation therapy
Neoplasms
medicine
Animals
Humans
Radiology
Nuclear Medicine and imaging
Molecular Targeted Therapy
Stem Cell Niche
biological properties
Clinical Trials as Topic
Cluster of differentiation
business.industry
Genetic Variation
Cancer
Cell Differentiation
General Medicine
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Radiation therapy
Cell Transformation
Neoplastic
Treatment Outcome
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Neoplastic Stem Cells
Cancer research
Stem cell
Anti-cancer stem cells therapy
Carcinogenesis
business
Biomarkers
Signal Transduction
Zdroj: Journal of Cancer Research and Therapeutics, Vol 14, Iss 7, Pp 1469-1475 (2018)
ISSN: 1998-4138
0973-1482
Popis: Increasing studies have demonstrated that most tumors consisted a subpopulation of cells with stem cell properties, known as cancer stem cells (CSCs). Accumulating evidence indicated that CSCs may be critical driving force for several types of cancer. Hence, it was necessary to develop therapeutic approaches specifically targeting CSCs. In this review, first, the biological properties of CSCs were introduced, including the self-renewal and differentiation, high tumorigenesis and invasiveness, resistance to chemotherapy and radiotherapy, genetic and epigenetic variations. Meanwhile, CSCs-targeted therapeutic strategies were summarized, including targeting cell surface markers, signaling pathways, CSC niches, differentiation therapy, and drug resistance for CSCs. Furthermore, clinical trials on anti-CSCs therapies supported the efficacy of these therapies, as well as their combination with conventional chemotherapy and radiotherapy. CSCs could be significantly eradicated, eventually resulting in inhibited tumor growth, metastasis, and recurrence. Thus, selectively targeting CSCs with various agents may be a novel and promising therapeutic strategy against cancer.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje