Long-Lasting Tumor Response in Patients with Panitumumab Monotherapy for Chemorefractory Metastatic Colorectal Carcinoma - A Report of Two Cases
| Autor: | S. Cameron, B. Tschechne, G. Ramadori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty Bevacizumab Colorectal cancer medicine.disease_cause lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Panitumumab Fourth-line therapy 030212 general & internal medicine business.industry Metastatic colorectal carcinoma Combination chemotherapy medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health Oxaliplatin Irinotecan Tolerability 030220 oncology & carcinogenesis Panitumumab monotherapy KRAS business Published: May 2010 medicine.drug |
| Zdroj: | Case Reports in Oncology Case Reports in Oncology, Vol 3, Iss 2, Pp 154-159 (2010) |
| Popis: | BACKGROUND: Second as well as higher-line therapies have a significant influence on progression-free and overall survival of metastatic colorectal cancer patients. However, treatment of late-stage disease remains suboptimal. Therefore, the introduction of new, effective and well-tolerated agents is of major importance. Case Reports: Here we describe the cases of 2 patients with metastatic KRAS wild-type colorectal cancer who received a fourth-line monotherapy with panitumumab after failure of 5-fluorouracil, irinotecan, oxaliplatin, and bevacizumab. RESULTS: Both patients achieved a partial remission, and for 11.5 and 18 months, respectively, they had a stable disease with initial reduction in the tumor marker carcinoembryonic antigen. Both patients reported a good tolerability of the treatment with improved quality of life (compared to receiving combined chemotherapy). CONCLUSION: Panitumumab monotherapy is an effective and well tolerated treatment of metastatic colorectal cancer in extensively pretreated KRAS wild-type patients. Our data have shown a response to panitumumab monotherapy for more than 11 months. peerReviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|