Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells
| Autor: | Xiang-Lan Piao, Shao-Fang Xing, Dao-Jin Chen, Hui-Min Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Clinical Biochemistry
Cell Molecular Conformation Pharmaceutical Science Antineoplastic Agents Biochemistry Structure-Activity Relationship Cell Line Tumor Drug Discovery medicine Carcinoma Humans Cytotoxic T cell Gynostemma pentaphyllum Molecular Biology Cell Proliferation A549 cell Lung Dose-Response Relationship Drug biology Plant Extracts Chemistry Organic Chemistry respiratory system biology.organism_classification medicine.disease Triterpenes Gynostemma respiratory tract diseases medicine.anatomical_structure Immunology Cancer research Molecular Medicine Non small cell Drug Screening Assays Antitumor |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:186-191 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2013.11.043 |
| Popis: | The activity of gypenosides and gynogenin of Gynostemma pentaphyllum against non-small cell lung carcinoma (NSCLC) A549 cells was investigated to identify the structural characteristics of gypenosides and gynogenin to have anti-NSCLC activity. Of the tested dammarane-type compounds, 20S-dammar-24-en-2α,3β,12β,20-tetrol showed the strongest activity against A549 cells. Based on the structure and cytotoxic activity relationships of gypenosides and gynogenin, the OH group in C-2, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells. |
| Databáze: | OpenAIRE |
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