Rapid Point-Of-Care Breath Test for Biomarkers of Breast Cancer and Abnormal Mammograms
| Autor: | Roy I. Lalisang, Peter D. Kaplan, Marc B. I. Lobbes, Mayur Mundada, J. David Beatty, Urvish Patel, Nadine Pappas, Jan Huston, Michael Phillips, Renee N. Cataneo, Philippe Lambin |
|---|---|
| Přispěvatelé: | Interne Geneeskunde, Radiotherapie, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Pathology Epidemiology Papillary Carcinomas Invasive Ductal Carcinoma lcsh:Medicine Diagnostic Radiology Benign Breast Tumors 0302 clinical medicine Area under curve Cancer screening Breast Tumors Young adult skin and connective tissue diseases lcsh:Science 0303 health sciences Chromatography Multidisciplinary medicine.diagnostic_test Carcinoma Ductal Breast 3. Good health Chemistry Ductal Carcinoma in Situ Breath Tests 030220 oncology & carcinogenesis Area Under Curve Medicine Female Invasive Lobular Carcinoma Radiology Monte Carlo Method Cancer Screening Mammography Research Article Biotechnology Adult medicine.medical_specialty Drugs and Devices Adolescent Point-of-Care Systems Breast Neoplasms Bioengineering Medical Devices 03 medical and health sciences Young Adult Breast cancer Diagnostic Medicine Internal medicine Biopsy medicine Biomarkers Tumor Cancer Detection and Diagnosis Early Detection Humans Biology 030304 developmental biology Point of care Gas Chromatography Breath test business.industry lcsh:R Cancers and Neoplasms medicine.disease Biomarker Epidemiology ROC Curve Multivariate Analysis Women's Health lcsh:Q business Biomarkers General Pathology |
| Zdroj: | PLOS ONE, 9(3):e90226. Public Library of Science PLoS ONE, Vol 9, Iss 3, p e90226 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background: Previous studies have reported volatile organic compounds (VOCs) in breath as biomarkers of breast cancer and abnormal mammograms, apparently resulting from increased oxidative stress and cytochrome p450 induction. We evaluated a six-minute point-of-care breath test for VOC biomarkers in women screened for breast cancer at centers in the USA and the Netherlands. Methods: 244 women had a screening mammogram (93/37 normal/abnormal) or a breast biopsy (cancer/no cancer 35/79). A mobile point-of-care system collected and concentrated breath and air VOCs for analysis with gas chromatography and surface acoustic wave detection. Chromatograms were segmented into a time series of alveolar gradients (breath minus room air). Segmental alveolar gradients were ranked as candidate biomarkers by C-statistic value (area under curve [AUC] of receiver operating characteristic [ROC] curve). Multivariate predictive algorithms were constructed employing significant biomarkers identified with multiple Monte Carlo simulations and cross validated with a leave-one-out (LOO) procedure. Results: Performance of breath biomarker algorithms was determined in three groups: breast cancer on biopsy versus normal screening mammograms (81.8% sensitivity, 70.0% specificity, accuracy 79% (73% on LOO) [C-statistic value], negative predictive value 99.9%); normal versus abnormal screening mammograms (86.5% sensitivity, 66.7% specificity, accuracy 83%, 62% on LOO); and cancer versus no cancer on breast biopsy (75.8% sensitivity, 74.0% specificity, accuracy 78%, 67% on LOO). Conclusions: A pilot study of a six-minute point-of-care breath test for volatile biomarkers accurately identified women with breast cancer and with abnormal mammograms. Breath testing could potentially reduce the number of needless mammograms without loss of diagnostic sensitivity. |
| Databáze: | OpenAIRE |
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