Superficial thrombophlebitis and risk for recurrent venous thromboembolism
| Autor: | Hugo Partsch, Peter Quehenberger, Verena Schönauer, Erich Minar, Mirko Hirschl, Paul A. Kyrle, Barbara Schneider, Sabine Eichinger, Ansgar Weltermann, Christine Bialonczyk |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Observation Thrombophlebitis Cohort Studies Recurrence Risk Factors Internal medicine Thromboembolism medicine Factor V Leiden Humans Superficial thrombophlebitis Prospective Studies cardiovascular diseases Risk factor Aged Lupus anticoagulant Factor VIII business.industry Incidence Middle Aged medicine.disease equipment and supplies Pulmonary embolism Surgery Relative risk Prothrombin G20210A Female business Pulmonary Embolism Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of Vascular Surgery. 37(4):834-838 |
| ISSN: | 0741-5214 |
| DOI: | 10.1067/mva.2003.157 |
| Popis: | Objective: Superficial thrombophlebitis (ST) is a frequent and potentially serious disease if complicated with venous thromboembolism (VTE). Data on risk factors and incidence rates for ST are scarce. It is also unknown whether ST is a risk factor for recurrence of VTE. Methods: After discontinuation of secondary thromboprophylaxis for a first spontaneous VTE, we prospectively observed 615 patients on average for 30 ± 26 months. Patients with natural coagulation inhibitor deficiency, lupus anticoagulant, or cancer, who were pregnant, or were receiving long-term antithrombotic therapy were excluded. The study outcomes were occurrence of symptomatic ST or objectively documented recurrent symptomatic VTE. Results: ST developed in 45 patients (7.3%) with a first VTE. High factor VIII concentration emerged as an independent risk factor for ST (relative risk [RR], 2.0; 95% confidence interval [CI], 1.0-5.2), compared with lower levels after adjustment for age and sex; factor V Leiden and prothrombin G20210A concentration; hyperhomocysteinemia; high body mass index; and duration of oral anticoagulation therapy. VTE recurred in 12 (27%) of 45 patients with ST and in 67 (12%) of 570 patients without ST. In patients with VTE, subsequent ST emerged as an independent risk factor for recurrent VTE. Patients with ST had twofold higher RR (2.1; 95% CI, 1.0-4.2) for recurrence than did patients without ST after adjustment for putative confounding variables. Conclusion: Patients with a first spontaneous VTE and subsequent ST are at increased risk for recurrent VTE. High factor VIII concentration is an independent risk factor for ST. (J Vasc Surg 2003;37:834-8.) |
| Databáze: | OpenAIRE |
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