Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis
| Autor: | Cathy L. Brizek, Vincent A. Pellegrini, Jeffrey B. Frank, Sheldon Schlaff, K.C. Worrilow |
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| Rok vydání: | 1995 |
| Předmět: |
Cytoplasm
medicine.medical_specialty medicine.medical_treatment Endometriosis Physiology Fertilization in Vitro Biology Genetics medicine Humans Human embryogenesis Genetics (clinical) Retrospective Studies Cell Nucleus Organelles Gynecology Microscopy Video In vitro fertilisation Incidence (epidemiology) Embryogenesis Obstetrics and Gynecology Embryo General Medicine medicine.disease Oocyte Human genetics Blastocyst Phenotype medicine.anatomical_structure Reproductive Medicine Female Infertility Female Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 12:106-112 |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/bf02211378 |
| Popis: | Purpose : After noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls. Methods : A total of 235 embryos representing 30 women undergoing 56 cycles of in vitro fertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval. Results : Several of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis. Conclusions : The incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses. |
| Databáze: | OpenAIRE |
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