Combined effects of soy isoflavone and fish oilon ovariectomy-induced bone loss in mice
| Autor: | Hyounju Kim, Akiyo Matsumoto, Kazuharu Suzuki, Mariko Uehara, Yoshiko Ishimi, Raina Uchida, Hiroshige Chiba |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Ratón Ovariectomy Endocrinology Diabetes and Metabolism Osteoporosis Flavonoid Bone resorption Mice Fish Oils Endocrinology Bone Density Internal medicine medicine Animals Orthopedics and Sports Medicine Femur Bone Resorption Safflower Oil chemistry.chemical_classification Chemistry Body Weight Uterus Feeding Behavior Organ Size General Medicine medicine.disease Fish oil Isoflavones Diet Mice Inbred C57BL Osteopenia Bone-resorbing cytokines Ovariectomized rat Calcium Drug Therapy Combination Female Polyunsaturated fatty acids Soybeans Biomarkers Polyunsaturated fatty acid |
| Zdroj: | Journal of Bone and Mineral Metabolism. 29(4):404-413 |
| ISSN: | 0914-8779 |
| Popis: | Both soy isoflavone and n-3 polyunsaturatedfatty acids are known to reduce the levels of bone-resorbingcytokines; however, the synergistic effects of these foodingredients have not been examined yet. This study wasperformed to elucidate the effect of concomitant intake ofsoy isoflavone and fish oil on bone mass in ovariectomizedmice. Eight-week-old ddY female mice were subjectedto ovariectomy (OVX) or sham surgery, and then fed anAIN-93G with safflower oil (So) as a control lipid source,isoflavone-supplemented safflower oil (So ? I), fish oilinstead of safflower oil (Fo) or isoflavone-supplemented fishoil (Fo ? I) for 4 weeks. Femoral bone mineral density wassignificantly decreased by OVX; however, this decrease wasinhibited by the intake of isoflavone and/or fish oil. Histomorphometricanalyses showed that bone volume and trabecularthickness in the distal femoral trabecular bone weresignificantly lower in the So group than in the sham group,but those were restored in the Fo ? I groups. The number ofosteoclasts was significantly decreased by isoflavone intake Original article. オンライン版はSpringerLinkで The Japanese Society for Bone and Mineral Research and Springer 2010. 45p. |
| Databáze: | OpenAIRE |
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