Macrolide-Resistant Mycoplasma genitalium in Southeastern Region of the Netherlands, 2014-2017
| Autor: | Sharon Kuster, Liesbeth Martens, Wilco de Vos, Ferry Hagen, Hanneke Berkhout, Maikel Kersten |
|---|---|
| Přispěvatelé: | Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Medical Mycology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Sexually Transmitted Diseases
Bacterial Sexually transmitted disease Male History Epidemiology Drug Resistance lcsh:Medicine Mycoplasma genitalium/drug effects Mycoplasma genitalium Drug resistance Azithromycin 0302 clinical medicine Medicine Macrolide-Resistant Mycoplasma genitalium in Southeastern Region of the Netherlands 2014–2017 Public Health Surveillance 030212 general & internal medicine bacteria Netherlands biology Macrolide resistant Bacterial sexually transmitted disease Macrolides/pharmacology Middle Aged 21st Century Anti-Bacterial Agents Infectious Diseases Female Macrolides Seasons medicine.drug Microbiology (medical) Adult medicine.medical_specialty macrolide resistance medicine.drug_class 030231 tropical medicine Sexually Transmitted Diseases Bacterial/epidemiology Sexually Transmitted Diseases Netherlands/epidemiology History 21st Century lcsh:Infectious and parasitic diseases Macrolide Antibiotics Anti-Bacterial Agents/pharmacology molecular diagnostics 03 medical and health sciences Young Adult Antibiotic resistance Internal medicine Drug Resistance Bacterial Humans lcsh:RC109-216 Mycoplasma Infections antimicrobial resistance Bacterial/epidemiology business.industry Genitourinary system Research lcsh:R the Netherlands biology.organism_classification bacterial infections and mycoses Mycoplasma Infections/drug therapy business |
| Zdroj: | Emerging Infectious Diseases, 25(7), 1297-1303. Centers for Disease Control and Prevention (CDC) Emerging Infectious Diseases Emerging Infectious Diseases, Vol 25, Iss 7, Pp 1297-1303 (2019) |
| ISSN: | 1080-6040 |
| Popis: | Mycoplasma genitalium infections of the urogenital tract are usually treated with azithromycin; however, for the past several years, rates of azithromycin treatment failure have increased. To document the occurrence and frequency of macrolide resistance-mediating mutations (MRMMs) in M. genitalium infections, we collected 894 M. genitalium-positive samples during April 2014-December 2017 and retrospectively tested them for MRMMs. We designated 67 samples collected within 6 weeks after a positive result as test-of-cure samples; of these, 60 were MRMM positive. Among the remaining 827 samples, the rate of MRMM positivity rose from 22.7% in 2014 and 22.3% in 2015 to 44.4% in 2016 but decreased to 39.7% in 2017. Because of these high rates of MRMMs in M. genitalium infections, we recommend that clinicians perform tests of cure after treatment and that researchers further explore the clinical consequences of this infection. |
| Databáze: | OpenAIRE |
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