Autonomic Nervous System and Diabetes: Histological and Histochemical Study of the Autonomic Nerve Fibers of the Urinary Bladder in Diabetic Patients
| Autor: | Isaac Faerman, Leticia Glocer, Mario Maler, Mauricio Jadzinsky, Enrique Alberto Alvarez, Dora Fox, David Celener |
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| Rok vydání: | 1973 |
| Předmět: |
Adult
Diabetic neuropathy Biopsy Endocrinology Diabetes and Metabolism Urinary Bladder Autonomic Nervous System Diabetes mellitus Diabetes Mellitus Internal Medicine Cholinesterases Humans Medicine Myelin Sheath Autonomic nerve fibers Cholinesterase Urinary bladder biology medicine.diagnostic_test business.industry Muscle Smooth Anatomy Middle Aged medicine.disease Axons Microscopy Electron Autonomic nervous system medicine.anatomical_structure Myelin sheath biology.protein Autopsy business |
| Zdroj: | Diabetes. 22:225-237 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.22.4.225 |
| Popis: | Reports on the histologic aspects of the autonomic nerves in diabetics are infrequent. This investigation was carried out to study histologically and histochemically the autonomic nerve fibers of the urinary bladder wall in ten diabetic patients. Of the five subjects examined by biopsy, four showed damage of nerve fibers; absence of cholinesterase activity was the only finding in the fifth patient who had chemical diabetes. In four autopsies we found alterations in all the cases. The lesions appeared as beaded or spindle-shaped fibers or small vacuolated or uniformly thickened fibers. The most severe cases exhibited fragmentation of the fibers. Histochemical analysis demonstrated absence of cholinesterase activity in the muscle, in all cases, and absence or decrease of such activity in the nerves in all but one case. Similar studies performed on eight nondiabetic subjects revealed no anatomic or histochemical lesions. The findings lead to the hypothesis that diabetic neuropathy injures the biochemical phase ofthe myelin sheath in the first stage and the nerve fibers later. No previous reports on the subject here studied could be found in the literature. |
| Databáze: | OpenAIRE |
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