Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory
| Autor: | Carla Sanchis-Segura, Anna Miró-Padilla, Cristina Forn, Elisenda Bueichekú, Ricardo Broseta-Torres, César Ávila, Sonia Félix Esbrí, Álvaro Javier Cruz-Gómez, Naiara Aguirre |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Audiology multiple sclerosis working memory cognitive training 03 medical and health sciences 0302 clinical medicine Neuroplasticity N-back medicine Reaction Time Humans Learning 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Cognitive decline n-back Neuronal Plasticity Working memory business.industry Multiple sclerosis functional connectivity General Medicine medicine.disease Cognitive training Memory Short-Term Neurology Neurology (clinical) Analysis of variance business 030217 neurology & neurosurgery |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I |
| Popis: | Background: Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explored. Methods: This study examines the effects of n-back training on cognitive performance and functional connectivity (FC) in 29 MS patients and 29 healthy controls (HC). Baseline (S1) performance on 2- and 3-back tasks and FC within the fronto-parietal network were assessed before randomly splitting the sample into four subgroups: trained MS (MSt, n = 15), trained HC (HCt, n = 14), untrained MS (MSu, n = 14), and untrained HC (HCu, n = 15). The trained subgroups underwent adaptive n-back training (60 min/day; 4 days) and n-back task performance and FC were reassessed in a second session (S2). Results: As revealed by mixed two-way ANOVAs, trained participants (MSt and HCt) exhibited a significant increase in the number of correct responses and significantly reduced reaction times in S2. These performance improvements were accompanied by an increase in FC in the fronto-parietal pathways and statistically significant correlations between both effects were found. Conclusions: Computerised WM training results in behavioural and neuroplasticity positive effects that may be useful when trying to prevent or attenuate cognitive decline in MS patients. |
| Databáze: | OpenAIRE |
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